Rail Property’s tenanted office lots raise £900,000

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Developing at a premium

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Success As A Coach

first_imgPeople often wonder why some coaches are successful at a certain school while others are not.  It usually has nothing to do with his or her knowledge of the sport that they are coaching.  Most of the time it is the situation that presents itself.Some coaches simply don’t fit into the community.  Through no fault of their own, their background differs so much from the community they are in that they simply can’t find their niche.  To be successful, you have to sell your program to the young men and women you are coaching.  In some cases, you may be too gruff for your athletes.  In other cases, you may not be tough enough.There are many little things that come into play.  You may be trying to replace a legend or you may enter a program that is so down that a John Wooden couldn’t succeed.  As I stated earlier, the biggest thing about coaching is fitting into the program.  If I knew the answer, I would write a book on it.last_img read more

Sevilla accept City’s Navas offer

first_img No fee was mentioned by the club, but reports suggested a deal could be worth up to £24million. Navas has plied his trade at the Ramon Sanchez Pizjuan since making his debut back in 2003. In that time he has won two UEFA Cups and two Copa del Rey titles, as well as being part of the Spain squads that won the 2010 World Cup and Euro 2012. He will also join Silva in the squad for the upcoming Confederations Cup, which begins in Brazil later this month. His international career was delayed because of panic attacks he suffered as a younger player when away from Seville, a problem he has since overcome. He will join a club in City that are yet to confirm their new manager following the departure of Roberto Mancini, though the appointment of Manuel Pellegrini is widely thought to be imminent. Pellegrini will certainly know plenty about Navas having spent the last decade in Spain, at Villarreal, Real Madrid and Malaga. The 27-year-old, who has spent his entire professional career at Sevilla, is set to undergo a medical with City where, should he complete his transfer, he will join fellow Spain World Cup and European Championship-winner David Silva. A statement on the Sevilla website read: “Sevilla FC has accepted the offer of the English club, taking into account the will of the player, and he will undergo a medical.” Press Associationcenter_img Sevilla have accepted an offer from Manchester City for Spain winger Jesus Navas, according to the Spanish club.last_img read more

Warriors agree Downey deal

first_img The 33-year-old – whose transfer is subject to a medical – has spent the past two seasons with Munster, his second spell at Thomond Park, after previous stints at Leinster, Connacht, Italian side Calvisano and Northampton, where he made 148 appearances in five years. Downey’s final game with Munster was a 16-15 defeat away to Glasgow in the RaboDirect Pro12 play-off semi-finals in May. Glasgow have agreed to sign Ireland centre James Downey from Munster on a two-year contract. Press Associationcenter_img Downey, who made his international debut against Canada last summer, said: “This is a great opportunity for me to join an ambitious club and hopefully I can have a successful couple of years in Glasgow. “The squad gets stronger each year and reaching the RaboDirect Pro12 final for the first time last season shows the progress the club is making. I know I’ll have to work hard to get into the team. “I’m looking forward to playing at Scotstoun regularly in front of very passionate supporters. The atmosphere at the RaboDirect Pro12 play-off was incredible.” Warriors head coach Gregor Townsend said: “James is a quality player who will be an excellent addition to our squad. “He is a tough defender and brings real physicality when carrying the ball. “He has a lot of experience having played for Northampton and Munster, and has been involved in some epic European games. “This experience, as well as his rugby ability will help us to make further progress as a squad next season.” last_img read more

Update on the latest sports

first_imgThe Raptors put an emphatic stamp on their sweep by blasting the Nets, 150-122.The Raptors had two players score at least 20 points off the bench, led by 29 from Norman Powell. Serge Ibaka (ih-BAH’-kah) added 27 points on 12 of 14 shooting and grabbed 15 rebounds.Pascal Siakam (see-A’-kam) finished with 20 points and 10 boards as the lone Toronto starter with more than 10 points.The Raptors are 11-1 in the bubble, with the lone loss coming against Boston.The Celtics took advantage of an injury and defeating the 76ers, 100-106. The game changed when Tobias Harris crashed to the floor at the 2:40 mark of the third quarter. Without Harris, Boston went on a 12-0 run and eventually led 96-79 in the opening minutes of the fourth. — The Angels will face the Indians in the 2021 Little League Classic at Williamsport, Pennsylvania. The game is scheduled for Aug. 22 at Bowman Field in front of a crowd predominantly made up of players, coaches and parents in Williamsport for the Little League World Series. NHL-CAPITALS-REIRDEN FIREDCapitals fire coach Todd Reirden after 2 postseason letdownsWASHINGTON (AP) — Todd Reirden is out after just two seasons as head coach of the Washington Capitals.The Capitals won two division titles in each season under Reirden but failed to capture a playoff series. He replaced Barry Trotz, who led the team to the 2018 Stanley Cup before heading to the Islanders in a contract dispute. Popov is ranked No. 304 and dropped off the LPGA Tour last year. She hadn’t previously won on the LPGA Tour, the second-tier Symetra Tour or on the Ladies European Tour. — Rio Ruiz drove in four runs and the Orioles gained a four-game split by downing the Red Sox for the second straight day, 5-4. Winning pitcher Thomas Eshelman entered the game with two out in the first inning and walked his first batter before retiring his last 13.— Kiké (KEE’-kay) Hernández hit a three-run drive and Mookie Betts went deep twice in a seven-homer assault that propelled the Dodgers to an 11-3 pounding of the Rockies and a three-game sweep. The Dodgers have won 11 of 12 games overall and own the best record in baseball at 22-8 at the halfway point of this abbreviated season.— Fernando Tatis (tah-TEES’) Jr. made two spectacular plays at shortstop and Manny Machado hit a two-run home run in the eighth inning to help the Padres earn a 5-3 victory and a three-game sweep of the Astros. San Diego has won seven straight, all against Texas ballclubs.— Mike Yastrzemski (ya-STREHM’-skee) smacked a go-ahead homer on his 30th birthday to help the Giants pick up their season-high sixth consecutive win, 6-1 over Arizona. Alex Dickerson added a three-run homer off Hector Rondon (rahn-DOHN’) in the seventh to provide cushion and make it a 5-1 game.— Cubs ace Yu Darvish struck out 10 over seven innings of his career-high fifth consecutive victory, a 2-1 triumph over the White Sox. Kyle Schwarber belted a two-run homer in the sixth inning to help the Cubs end the White Sox’s seven-game winning streak. The Islanders completed a five-game series win against the Capitals on Thursday.INDYCAR-INDIANAPOLIS 500Sato claims second Indianapolis 500 crownINDIANAPOLIS (AP) — Takuma Sato snatched a second Indianapolis 500 victory as the Japanese racer held off Scott Dixon and ultimately won under caution.IndyCar officials declined to throw a red flag after a violent crash by Spencer Pigot (pee-ZHOH’) with just a handful of laps remaining. Pigot needed medical attention on the track, the crash scene was a debris field and there was no way the race could resume without a stoppage. Associated Press MLB-SCHEDULETigers shed Indians hexUNDATED (AP) — The Detroit Tigers have won a three-game series in Cleveland after absorbing 20 consecutive losses to the Indians.Tarik Skubal and Daniel Norris combined to pitch six innings of one-run ball in the Tigers’ 7-4 victory over the Indians. Miguel Cabrera drove in two and Detroit belted three home runs in the rubber match of the series.Jorge Bonifacio hit a two-run homer and Niko Goodrum and Grayson Greiner had solo shots for the Tigers. Kemba Walker poured in 32 points in his first NBA series-clinching win.Jayson Tatum finished with 28 points and a playoff career-high 15 rebounds.Harris had 20 points despite his lengthy absence in the second half. Joel Embiid (joh-EHL’ ehm-BEED’) finished with 30 points and 10 boards for Philadelphia.Also in NBA first-round action, Luka Doncic (DAHN’-chihch) drained a 3-pointer at the buzzer to give the Mavericks a 135-133 triumph over the Clippers, evening the series at two games apiece. Doncic was sensational despite playing on a badly sprained ankle, delivering 43 points, 17 rebounds and 13 assists.Trey Burke finished with 25 points and Tim Hardaway Jr. added 21 in a game that featured eight lead changes in OT. Elsewhere around the majors:— Nelson Cruz blasted his 10th homer and Marwin Gonzalez had two RBIs before closer Taylor Rogers dodged trouble in the ninth inning of the Twins’ 5-4 win against the Royals. Cruz hit a solo shot an estimated 453-feet to center field in the ninth inning for a two-run lead, helping Minnesota win its eighth series in nine tries this season.— Mark Canha (KAN’-ah) lifted a sacrifice fly in the 10th inning to give the Athletics a 5-4 win versus the Angels. Oakland trailed 4-2 before rallying on RBI singles by Stephen Piscotty (pihs-KAH’-tee) and Sean Murphy in the sixth.— Josh Fleming won his big league debut by pitching five innings of two-run ball in the Rays’ 5-4 decision over the Blue Jays. Austin Meadows drove in two runs and Brandon Lowe (low) provided an RBI single that put Tampa Bay ahead to stay.— Kyle Lewis and Austin Nola belted early solo home runs and Sam Haggerty’s two-run blow gave the Mariners a 4-0 lead in the fifth inning of a 4-1 win over the Rangers. Justin Dunn allowed just one hit over six scoreless frames before three relievers finished the combined three-hitter. A day after Denny Hamlin opened the doubleheader weekend with his sixth win to match Harvick and one-upped his closest rival to claim NASCAR’s regular-season title. Harvick has 56 career Cup victories to tie Kyle Busch for ninth on the career list.Martin Truex Jr. was second and Jimmie Johnson third. Johnson is on the bubble, four points outside of the cutoff with his fate to be decided under the lights at Daytona. NFL-NEWSNFL asks lab to check reliability of its COVID-19 testsUNDATED (AP) — The NFL has asked a New Jersey lab to investigate a new batch of COVID-19 test results amid reports from several teams of false positives. The league didn’t identify which teams got positive results, or how many there were. The Mavericks were without forward/center Kristaps Porzingis (KRIHS’-tahps pohr-ZIHN’-gihs) because of right knee soreness.Lou Williams pumped in 36 points and Kawhi (kah-WY’) Leonard had 32 for the Clippers, who trailed by eight heading into the fourth quarter.NBA-NEWSFines from Magic-Bucks scuffleLAKE BUENA VISTA, Fla. (AP) — Magic forward James Ennis and Bucks forward Marvin Williams have been fined $15,000 each for a fight that led to their ejections from Game 3 of their teams’ first-round playoff series Saturday. Ennis and Williams had been competing for rebounding position midway through the second quarter of the Bucks’ 121-107 victory. They exchanged shoves as they headed back up the floor. center_img Share This StoryFacebookTwitteremailPrintLinkedinRedditNBA PLAYOFFSRaptors, Celtics complete sweepsLAKE BUENA VISTA, Fla. (AP) — The Toronto Raptors and Boston Celtics will tangle in the second round of the NBA playoffs after completing four-game sweeps. Dixon dominated the race and asked on his radio if IndyCar was going to give the drivers a final shootout to the checkered flag, NASCAR style. But the five-time Indy-Car champion had to settle for second after Sato led him across the finish line under yellow. Sato’s teammate, Graham Rahal (RAY’-hahl), was third.NASCAR-DOVERHarvick gets 7th win of seasonDOVER, Del. (AP) — Kevin Harvick has regained the NASCAR Cup Series victory lead by dominating Sunday’s race at Dover International Speedway. — The banged-up Jets received a boost on the practice field with the returns of linebacker Avery Williamson and tight ends Ryan Griffin and Daniel Brown to team drills. Williamson and Griffin opened training camp on the active/physically unable to perform list. Brown was on the non-football injury list with an ankle injury.— Patriots wide receiver N’Keal Harry was back on the field for Sunday’s practice in shells and shorts, but second-year quarterback Jarrett Stidham was held back during combined team drills after also being limited Friday.PGA-NORTHERN TRUSTJohnson back at No. 1 after dominant winNORTON, Mass. (AP) — Dustin Johnson played the final two holes in near darkness after a late storm delay and finished with a birdie for an 8-under 63 and an 11-shot victory over Harris English at The Northern Trust. Pence designate by GiantsUNDATED (AP) — The San Francisco Giants have cut ties with outfielder Hunter Pence, ending a second stint with the fan favorite that didn’t go nearly as well as his first.The 37-year-old was designated for assignment to clear a spot on the 40-man roster for utility man Daniel Robertson, who was acquired earlier in the day from the Rays for cash or a player to be named later.Pence was hitting just .096 with two home runs and six RBIs in 17 games. He was a fiery, emotional leader for the Giants from 2012-2018, helping anchor teams that won the World Series in 2012 and 2014. In other baseball news: Update on the latest sports Among teams reporting false positives, the Minnesota Vikings said they had 12, the New York Jets 10 and the Chicago Bears nine. Other teams that were affected are the Buffalo Bills, Pittsburgh Steelers, Philadelphia Eagles and Cleveland Browns. In other NFL news:— The Ravens have terminated the contract of seven-time Pro Bowl safety Earl Thomas. According to a statement released today by the team, Thomas was released “for personal conduct that adversely affected the Baltimore Ravens.” The action stems from Thomas’ fray with defensive back Chuck Clark at Friday’s practice after Thomas admittedly blew a coverage assignment. — Washington has released wideout Cody Latimer amid his legal issues before he practiced a single snap with the team. He was arrested in May and charged with a felony count of illegal discharge of a firearm. He also faces charges of second-degree assault, menacing, prohibited use of a weapon and reckless endangerment. — The Cardinals have signed veteran cornerback Dre Kirkpatrick to boost their secondary after a season-ending injury to Robert Alford. Kirkpatrick spent his first eight NFL seasons with the Bengals and has 10 career interceptions in 99 games, including 67 starts. It was the 22nd victory of his PGA Tour career and fifth in a FedEx Cup playoffs event, tied with Rory McIlroy for most. Johnson finished at 30 under and returned to No. 1 in the world. WOMEN’S BRITISH OPEN304th-ranked Popov wins Women’s British OpenTROON, Scotland (AP) — Sophia Popov became the first female golfer from Germany to capture a major title when she won the Women’s British Open by two strokes at Royal Troon. Popov went into the final round with a three-shot lead. She bounced back from a first-hole bogey by making five birdies in her 3-under 68. Jasmine Suwannapura was the runner-up after shooting 67. — Yadier (YAH’-dee-ehr) Molina had four hits and top prospect Dylan Carlson hit his first career homer as the Cardinals dumped the Reds, 6-2. Harrison Bader added a two-run shot for St. Louis, which won three of four in the series.— Outfielder Roman Quinn threw out Dansby Swanson at the plate to end the Phillies’ 5-4 win over the Braves. Alex Bohm, Rhys Hoskins and Didi Gregorius (DEE’-dee greh-GOHR’-ee-uhs) homered to give Philadelphia a 4-0 lead by the third inning.— Trea Turner was 3-for-3 with three RBIs and two runs scored in the Nationals’ lopsided victory over the Marlins, 9-3. Winning pitcher Anibal (AH’-nih-bahl) Sánchez allowed one run and five hits over a season-high seven innings. — Gregory Polanco’s two-run blast in the eighth inning pushed the Pirates past the Brewers, 5-4. Bryan Reynolds, Jarrod Dyson and Adam Frazier furnished RBI singles in the Pirates’ third straight win since a nine-game losing streak.MLB-NEWS August 23, 2020last_img read more

All-round display from TKR results in second win

first_img(ESPNCRICINFO) – An incisive new-ball display from Ali Khan and Jayden Seales put Jamaica Tallawahs into a hole which they could not climb out of as the Trinbago Knight Riders (TKR) dominated wire to wire in a seven-wicket win on Thursday night.Sunil Narine and Fawad Ahmed continued to keep Tallawahs pinned down in the middle overs, including a wicket maiden from Ahmed, while Andre Russell failed to launch at the death – scoring 25 at under a run a ball – as the Tallawahs sputtered to 135 for 8.Fidel Edwards produced a wicket maiden of his own for Tallawahs at the start of the chase, claiming Lendl Simmons with a skied slog to mid-off.But Narine bashed his second fifty in a row to steady Knight Riders, and teamed with Colin Munro in a 75-run stand before falling in the first over after drinks on a top-edged sweep off Sandeep Lamichhane to deep fine leg for Carlos Brathwaite’s second catch.But Brathwaite grassed two subsequent efforts in the field to sum up a subpar night for the Tallawahs. Munro ended unbeaten on 49 as a wide from Brathwaite down leg clinched the match with 11 balls to spare.The Knight Riders’ favourite son from the USA struck in the first over for the second match running, this time getting a top-edge from Chadwick Walton to swirl into the hands of Ahmed at short fine leg on the second ball of play.Seales then followed that up by trapping Nicholas Kirton on the back leg in front of middle with a beautiful in-swinger before Khan induced a mistimed pull from captain Rovman Powell that travelled gently to mid-on where Dwayne Bravo’s tumbling effort made it 19 for 3 in the third over.Glenn Phillips did his best to breathe life back into the innings. He struck five fours and four sixes in his measured knock but his good fortune departed when he whipped a leg stump half-volley from Seales straight to Bravo on the rope at deep backward square leg in the 16th over to make it 99 for 6.Solid death bowling from Khan and Bravo ensured Russell was held in check until he drove Bravo to Munro at long-off to extinguish the last remaining threat.The new-age all-rounder pounded the boundary all around the ground in his 53 off 38 balls, but perhaps most impressive were a pair of lofted drives over extra cover on one leg against Russell. The left-hand batsman showed his flair with a pair of pirouette punches to clear the off side and leave the Tallawahs flummoxed.For the most part, both he and Munro countered the challenge of Mujeeb Ur Rahman and Lamichhane well. Munro took guard well outside off-stump to counter Mujeeb’s line of attack that aimed for the wide lines while both Narine and Munro mostly stayed deep to play Lamichhane late with his steady diet of googlies landing short enough to be worked comfortably through the off-side.Narine was finally undone trying to go through the leg-side against the turn of Lamichhane’s wrong-un, but not before he had put Knight Riders on course to complete a mostly stress-free chase.last_img read more

Root left out of Twenty20 squad to face Aussies

first_imgENGLAND Test captain Joe Root has been left out of the Twenty20 squad for the three-game series against Australia.Root is in the one-day squad with Chris Woakes while Jos Buttler, Jofra Archer, Sam Curran and Mark Wood are included in both squads.Ben Stokes, who missed the last two Tests against Pakistan to visit his ill father in New Zealand, is left out.The three-match Twenty20 series starts on Friday with three one-day internationals from 11 September.The second T20, on Sunday, will be live on BBC One and BBC iPlayer from 13:50 BST.T20 squad: Eoin Morgan (captain), Moeen Ali, Jofra Archer, Jonny Bairstow, Tom Banton, Sam Billings, Jos Buttler, Sam Curran, Tom Curran, Joe Denly, Chris Jordan, Dawid Malan, Adil Rashid, Mark Wood. Reserves: Liam Livingstone, Saqib Mahmood.ODI squad: Eoin Morgan (captain), Moeen Ali, Jofra Archer, Jonny Bairstow, Tom Banton, Sam Billings, Jos Buttler, Sam Curran, Tom Curran, Adil Rashid, Joe Root, Chris Woakes, Mark Wood. Reserves: Joe Denly, Saqib Mahmood.Opener Jason Roy has been left out as he recovers from a side strain but he will stay inside the bio-secure bubble with a view to demonstrating his fitness for the one-dayers.Reece Topley, David Willey, Liam Dawson and James Vince – who only scored 57 in three innings – drop out of the one-day squad that faced Ireland with batsman Joe Denly and bowler Saqib Mahmood demoted to reserves.Willey and all-rounder Lewis Gregory drop out of the T20 squad that is currently facing Pakistan while Mahmood again drops to the reserves.Root’s omission from the T20 squad means he will not have featured in any of England’s last four series in the format with a World Cup scheduled to start in India in October 2021.The 29-year-old opted to play in the Vitality Blast for Yorkshire rather than rest after the Pakistan Test series, and has still been left out despite scoring 65 against Notts on Monday and 64 against Derbyshire on Sunday.Despite that, National Selector Ed Smith says no “doors are closed” for Root.“At the moment we are setting up in a particular way as an XI in T20 cricket and Joe is not in that,” said Smith.“The decision then moves to ‘if he’s not in that starting XI at the moment, although no doors as closed to him in the future and that could easily change, where is the right place for Joe?’“He plays so much cricket and gives so much to England every time he plays and the decision is that it is not right to have him in the squad if he’s not likely to be starting.“Moving forward that could easily change – we’ve all seen that Joe is an easily adaptable and outstanding batsman and he could easily come back into the reckoning.”Head coach Chris Silverwood will be in charge for the series after assistants Paul Collingwood and Graham Thorpe took charge of the series against Ireland and Pakistan respectively.The three ODIs form part of the ICC Men’s Cricket World Cup Super League which will determine qualification for the 2023 World Cup, with the top seven teams automatically booking their spot at the tournament in India.(BBC Sport).last_img read more

Skaneateles boys hoops beats Cazenovia; Solvay hits state rankings

first_img Tags: boys basketballJ-EMarcellusskaneatelesSolvay The two Lakers sides went through a closely played first half. Nate Fouts’ 10 points helped Skaneateles inch in front, 24-23, and it extended its margin to 34-26 before Cazenovia went on a 15-2 run to close the third quarter.Fighting back, Skaneateles found itself in a tense struggle through the final minutes, neither team able to produce much for long stretches.Down by two, 46-44, Skaneateles evened it up with Jack Whirtley’s free throws with 29 seconds to play. A strong week that included a road victory at Skaneateles helped land the Solvay boys basketball team in the no. 24 spot in last week’s state Class B rankings.But while Skaneateles fell out of the state poll, it made a case to return last Wednesday night by rallying late and, with a dramatic finish, knocking off Cazenovia 48-46.Going in, Skaneateles was 10-3, but had lost two of its previous three games and now dealt with a Cazenovia side that had an 11-3 mark and was state-ranked at no. 27.center_img Then, after a Cazenovia miss, the home Lakers, not calling a time-out, rushed downcourt, Whirtley passing it to Max Wamp, who put in the go-ahead basket with less than three seconds left.When Cazenovia was unable to answer, Skaneateles had one of its best wins of the season, Fouts having finished with 16 points and Whirtley with 15 points, the same total as Cazenovia’s Alex Moesch, who led his side.Now it was up to the Bearcats to live up to that billing, and in last Tuesday’s game at Chittenango it did so, relying mostly on a strong third quarter to beat the Bears 53-47.A low-scoring first half on both ends left Solvay clinging to a 25-21 lead, but it outscored Chittenango 14-4 in the third period, which allowed it to withstand a late Bears push.Brock Bagozzi and Elijah Wright led the way, earning 14 points apiece, while Will Evans stepped up with 11 points and Jaimen Bliss had eight points as Chittenango’s Bryce Bishop led all scorers with1 7 points.Solvay went for five in a row Thursday against Holland Patent and attained it, the Bearcats again taking over in the third quarter thanks to a 20-9 run as it won 72-50 over the Golden Knights.Bagozzi’s 22 points included three 3-pointers and help from Wright, who again had 14 points, and Bliss, who stepped up for 13 points as Brendon Carolina got six points.Marcellus, hammered on Jan. 17 in a loss to Bishop Ludden, rebounded well in last Tuesday’s game against Cato-Meridian, bashing the Blue Devils 77-49.A 17-4 second-quarter push broke the game open, the Mustangs leading 41-21 by halftime as Matt Kershaw would earn 22 points and Luke Ingianni got 15 points. Will Kimber, Corey Cangemi and Jared Sammon had eight points apiece.Taking on Hannibal two nights later, Marcellus won again, 61-37, this despite trailing 28-27 at the end of an indifferent first half.But the Mustangs outscored the Warriors 24-2 in the fourth quarter, a rush to the finish line that saw Ingianni and Ryan Sammon each finish with 13 points, while Cangemi and Tristan Jarvi each had nine points.Jordan-Elbridge was upended last Wednesday in a narrow 52-51 defeat to state Class C no. 12-ranked Onondaga, who moved to 11-2 despite Dakota Holbrook (16 points), Alex Pond (12 points) and Tyler Waldron (11 points) all hitting double figures for the Eagles.But the Eagles prevailed 59-48 over Mater Dei Academy two nights later to improve to 10-5 overall. Holbrook had 20 points, including a pair of 3-pointers, while Pond and Jeremy Meili both finished with 14 points.Share this:FacebookTwitterLinkedInRedditComment on this Story last_img read more

Researchers link mechanism with two diseases

first_imgUSC researchers recently discovered a cellular mechanism that accounts for at least 10 percent of each amyotrophic lateral sclerosis (ALS) and frontotemporal dementia cases. The gene mutation in the C9 gene increases the risk of ALS and frontotemporal dementia cases. Photo from USC Keck School of Medicine News Release.The mechanism limits the number of “cellular janitors,” like lysosomes, in the nervous system leading to increased risk for the two neurodegenerative diseases.Yingxiao Shi and Shaoyu Sebastian of the Justin Ichida Laboratory at USC said that a mutation in a gene labeled “C9ORF72” leads to toxicity in nerve cells, which is a factor in at least 10 percent of both ALS and frontotemporal diseases.The C9ORF72, or C9 gene, produces a protein required to make lysosomes that grab and remove toxic proteins and garbage, according to Ichida, an assistant professor of stem cell and regenerative medicine at the Keck School of Medicine. It acts as a cellular chain reaction. Without a normal number of lysosomes, the motor nerve cells collect toxic garbage, which includes a large toxic protein produced by the C9 mutation and molecules that receive signals from the glutamate and die.“We figured out how the most common form of ALS causes nerve cell death, and nerve cell death is what causes patients to become paralyzed or lose control of neuromuscular functions,” Ichida said in a news release from Keck.To understand the process, the researchers removed blood from ALS patients carrying the C9 mutation and reprogrammed these blood cells into motor nerve cells that degenerate and die in the disease, according to the news release. In addition, they extracted blood from healthy patients, reprogrammed these blood cells into motor nerve cells and used gene editing to delete the C9 gene, according to the news release.Both groups with the mutated motor nerve cells had a reduced number of proteins normally made by the C9 gene. By adding the supplemental C9 protein, the researchers were able to stop the motor nerve cells from degenerating.The Ichida Lab is now using the patient-derived motor nerve cells to test potential drugs, focusing on those that affect lysosomes. They are looking to find potential drugs that slow or stop degeneration of these motor nerve cells, and hope to eventually use these drugs on patients, according to the news release.last_img read more